Why Should You Work With MUSC?


At the Medical University of South Carolina (MUSC), we offer nurses a variety of career paths. As a new RN grad or experienced nurse, you can enjoy a supportive team environment, collaborate across disciplines, and help us deliver award-winning patient care to our communities.

Your Input Matters

Nurses are essential to everything we do, and we value your input. Participate in nurse-driven research and help drive practice improvement through our shared governance councils.

Your Role in Patient Care

Our patients and families are the central focus of our care model. You help us build the foundation of patient care in your relationships with your patients, their families, and your colleagues. 

Your Future at MUSC

We want to help you become the patient advocate and leader you're meant to be. MUSC offers professional and personal development opportunities at every stage of your nursing career. 

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The Medical University of South Carolina

Founded in 1824 in Charleston, MUSC is the state’s only comprehensive academic health system, with a mission to preserve and optimize human life in South Carolina through education, research and patient care. Each year, MUSC educates over 3,100 students in six colleges and trains 950+ residents and fellows across its health system. MUSC leads the state in federal and National Institutes of Health and research funding.

As the health care system of the Medical University of South Carolina, MUSC Health is dedicated to delivering the highest-quality and safest patient care while educating and training generations of outstanding health care providers and leaders to serve the people of South Carolina and beyond. In 2024, for the 10th consecutive year, U.S. News & World Report named MUSC Health University Medical Center in Charleston the No. 1 hospital in South Carolina. To learn more about clinical patient services, visit muschealth.org.

MUSC has a total enterprise annual operating budget of $7.1 billion. The 31,000 MUSC members include world-class faculty, physicians, specialty providers, scientists, contract employees, affiliates and care team members who deliver groundbreaking education, research, and patient care.

Full time, Full Time
 
MUSC Health Florence, SC, USA
Job Description Summary $20,000 Sign on Bonus Available for full-time day shift! Awesome state health benefits and retirement. Up to 6 weeks PAID Parental Leave. Please contact Recruiter Shannon Shaw at 843-674-2694 or shawsh@musc.edu to find out more! Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC003619 FLO - Surgiday (FMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 40 Work Shift Job Description Provides nursing care to patients using the nursing process (assessment, planning, implementation, and evaluation). Directs and leads other assigned team members and collaborates with multidisciplinary team members to provide age/developmentally appropriate care in accordance with nursing standards of care and practice. Provide patient/family centered care using the nursing process and focusing on the physical, emotional, spiritual, cultural, religious, and...

Full time, Full Time
 
MUSC Health Columbia, SC, USA
Job Description Summary Job Description Summary MUSC Health – Columbia Medical Center Northeast is seeking a skilled and motivated Advanced Practice Provider (APP) to join our Neurological Surgery team in northeastern Columbia, SC. This is an exceptional opportunity for an APP who thrives in the operating room and enjoys the balance of both surgical and clinical practice. Entity MUSC Community Physicians (MCP) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001861 MCP - Columbia NE Neurosurg Gatewy Pay Rate Type Hourly, Salary Pay Grade Health-33 Scheduled Weekly Hours 40 Work Shift Job Description Job Summary/ Purpose : MUSC Health – Columbia Medical Center Northeast is seeking a skilled and motivated Advanced Practice Provider (APP) to join our Neurological Surgery team in northeastern Columbia, SC. This is an exceptional opportunity for an APP who thrives in the operating room and enjoys the balance of both surgical and...

Full time, Full Time
 
MUSC Health Columbia, SC, USA
Job Description Summary MUSC Health – Columbia Medical Center Northeast is seeking a skilled and motivated Advanced Practice Provider (APP) to join our Neurological Surgery team in northeastern Columbia, SC. This is an exceptional opportunity for an APP who thrives in the operating room and enjoys the balance of both surgical and clinical practice. Entity MUSC Community Physicians (MCP) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001861 MCP - Columbia NE Neurosurg Gatewy Pay Rate Type Hourly, Salary Pay Grade Health-33 Scheduled Weekly Hours 40 Work Shift Job Description Job Summary/ Purpose : MUSC Health – Columbia Medical Center Northeast is seeking a skilled and motivated Advanced Practice Provider (APP) to join our Neurological Surgery team in northeastern Columbia, SC. This is an exceptional opportunity for an APP who thrives in the operating room and enjoys the balance of both surgical and clinical practice. In this...

Full time, Full Time
 
MUSC Health Charleston, SC, USA
Job Description Summary The Registered Nurse II / Relief Staff Leader (RSL) reports to the Nurse Manager. Under general supervision, the RN II/RSL provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process. This role delivers safe and effective care and interacts with other members of the health care team to achieve desired outcomes. As assigned, this position provides department/shift leadership in RSL role. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC000514 CHS - MedSurg 7E (Main) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Rotating (United States of America) Job Description Provides nursing care to patients using the nursing process (assessment, planning, implementation, and evaluation). Directs and leads other assigned team members and...

Full time, Full Time
 
MUSC Health Charleston, SC, USA
Job Description Summary Under general supervision, the Registered Nurse RSL II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process; delivers safe and effective care and interacts with other members of the health care team to achieve desired results. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC000237 CHS - ACU (Acute Care) 7B (Main) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Day (United States of America) Job Description Under general supervision, the RN II/Relief Staff Leader (RSL) provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process. This role delivers safe and effective care and interacts with other members of the health...

Full time, Full Time
 
MUSC Health North Charleston, SC, USA
Job Description Summary The RN will support Nephrology, Plastic Surgery, GI Surgery, General Surgery, Surgical Oncology, and Neurosurgery areas. Responsible for quality patient care under the direction of a physician or licensed healthcare provider in a clinical practice. Duties to include rooming patients, taking vitals and health history, documenting in an electronic medical record, giving injections and assisting with minor procedures. Entity University Medical Associates (UMA) Only Employees and Financials Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001995 UMA AMB MULT North Area Clinic-Administration CC Pay Rate Type Hourly Pay Grade Health-27 Scheduled Weekly Hours 40 Work Shift Day (United States of America) Job Description Ensures accurate calibrations, cleaning and scheduled maintenance of clinical/lab equipment as required by OSHA, DHEC and UMA; tracked by documentation. Maintains and reviews...

Full time, Full Time
 
MUSC Health Columbia, SC, USA
Job Description Summary Job Description The next Residency Cohort begins July 13th, 2026 Applications closed on February 28, 2026. Interviews will be held in March 2026. Benefits: $10,000 Sign-on Bonus State Retirement, State Medical Benefits #1 Healthcare System in South Carolina Student Loan Reimbursement Tuition Assistance Certification Incentives Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC003730 COL - ICU (Intensive Care Unit) (DMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Nights (United States of America) Job Description Goal: This program’s goal is to foster nurse growth and critical care skills in a team-oriented environment. Details of the Program The Critical Care Residency Program is a supervised rotational residency tailored to the needs of the New Graduate Nurse. Unit details below, 4 East Progressive...

Full time, Full Time
 
MUSC Health Mount Pleasant, SC, USA
Job Description Summary The Ambulatory Registered Nurse II provides clinical nursing care to the patient and works alongside the provider team and other clinical staff during the patient’s clinic appointment. This includes utilizing the nursing process, order entry, providing patient education, assisting with procedures, charting in the EMR (EPIC), managing patient in-basket messages, and coordination of care. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC005552 CHS - East Cooper Oncology (offsite) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 40 Work Shift Day (United States of America) Job Description - $4,000 sign on bonus for ONS (Oncology Nursing Society) Certified Nurses & OCN (Oncology Certified Nurse ) • Both out of state and/or in state qualify • Not available for internal hires • The ONS Certification needs to be obtained prior to signing...

Part time, Part Time
 
MUSC Health Florence, SC, USA
Job Description Summary Excellent PRN opportunity for experienced Operating Room RNs! Please contact Recruiter Shannon Shaw at 843-674-2694 or shawsh@musc.edu to find out more. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC003612 FLO - Ambulatory Surgery Center (FMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 8 Work Shift Job Description Provides nursing care to patients using the nursing process (assessment, planning, implementation, and evaluation). Directs and leads other assigned team members and collaborates with multidisciplinary team members to provide age/developmentally appropriate care in accordance with nursing standards of care and practice. Provide patient/family centered care using the nursing process and focusing on the physical, emotional, spiritual, cultural, religious, and environmental needs. This includes providing for the...

Full time, Full Time
 
MUSC Health Orangeburg, SC, USA
Job Description Summary We are offering a $20,000 sign-on bonus for this full-time night shift position! MUSC Orangeburg Nursery is a Level II nursery that provides care for babies born at or after 32 weeks gestation and weigh 1500 grams or more who may have moderate health issues requiring additional monitoring support. We also provide well care to term newborns immediately after birth and throughout the length of their hospital stay until discharge. We have a lactation consultant on staff to promote breastfeeding to give moms education and support during the hospitalization and an after-hours/post discharge line for support at home. The nursery is staffed with neonatal nurses, neonatal nurse practitioners, and has access to neonatologists via telehealth. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC004754 ORBG - Nursery Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly...

Part time, Part Time
 
MUSC Health Orangeburg, SC, USA
Job Description Summary Unit Description: The MUSC Orangeburg Emergency Department is a Level III Trauma Center with 43 treatment areas. We proudly serve the surrounding communities of Orangeburg, Calhoun, Bamberg, and Barnwell counties for all their acute healthcare needs. As a Registered Nurse within our department, you will have the opportunity to work alongside a diverse healthcare team that utilizes research and best practice to provide the utmost care for our patients. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ PRN Cost Center CC004773 ORBG - Emergency Room Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 12 Work Shift Job Description Job Summary Provide professional nursing care within an assigned unit and coordinate care planning with other disciplines. Work Environment Regularly exposed to infectious, contagious and blood borne diseases. Contact with patients...

Full time, Full Time
 
MUSC Health Charleston, SC, USA
Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process; delivers safe and effective care and interacts with other members of the health care team to achieve desired results. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC000455 CHS - Heart Center - 3 (SJCH) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Job Description Entity/Organization: MUHA (Medical University Hospital Authority/Medical Center) Hours Per Week: 36 Scheduled Work Hours/Shifts: Rotating Up to a $30k sign-on bonus with a 3-year service agreement for external candidates who have a minimum of 2-years of relevant nursing experience. Job Summary/Purpose: Under general supervision,...

Full time, Full Time
 
MUSC Health Orangeburg, SC, USA
Job Description Summary Provide direct patient care according to established policies and procedures under the direction of a RN. Schedule: 3 x 12-hour shifts per week 7 pm - 7 am Every other weekend obligation Holiday obligation Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC004827 ORBG - IP Rehab Nursing Pay Rate Type Hourly Pay Grade Health-24 Scheduled Weekly Hours 36 Work Shift Nights (United States of America) Job Description Essential Functions: 1. Provide direct patient care according to established policies and procedures under the direction of a RN. 2. Administers medication according to scope of practice, performs reassessments, collects data, takes histories, initiates IV access, provide wound care and assists in activities of daily living. 3. Documents in the medical record, findings and information. 4. Communicate appropriate medical and clinical...

Full time, Full Time
 
MUSC Health Orangeburg, SC, USA
Job Description Summary Provides professional nursing leadership responsible for promoting and restoring patients' health by developing day-to-day management and long-term planning of the patient care area within an assigned unit. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC004748 ORBG - 4 West/Peds Pay Rate Type Salary Pay Grade Health-32 Scheduled Weekly Hours 40 Work Shift Job Description Work Environment: Regularly exposed to the risk of blood-borne diseases. Contact with patients under a wide variety of circumstances. Exposed to unpleasant elements (accidents, injuries, and illnesses). Subject to varying and unpredictable situations. Must be able to handle emergency or crisis situations. May perform emergency care. Occasionally subjected to irregular hours. Supervisory Responsibilities: Oversees daily operations providing supervision of the Clinical...

Full time, Full Time
 
MUSC Health Lancaster, SC, USA
Job Description Summary Be part of something meaningful from the ground up. Our newly opened Hematology & Oncology Clinic is looking for a compassionate, detail-oriented Licensed Practical Nurse (LPN) who wants to make a real difference in patients’ lives while helping shape a growing practice. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC005634 LAN - Hematology Oncology Outpatient Clinic (LMC) Pay Rate Type Hourly Pay Grade Health-24 Scheduled Weekly Hours 40 Work Shift Day (United States of America) Job Description Why Join Us? Work in a specialty clinic focused on patient-centered cancer care Be part of a collaborative, supportive team Make lasting connections with patients during their treatment journey Position Highlights Provide high-quality nursing care to hematology and oncology patients Support providers with clinical procedures and patient...

Full time, Full Time
 
MUSC Health Charleston, SC, USA
Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process; delivers safe and effective care and interacts with other members of the health care team to achieve desired results. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC000570 CHS - OR / Procedure - 2 & 3 (SJCH) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Job Description Hours Per Week : 36 Weekly schedule: Monday-Friday. 3–12-hour shifts; 830a-9p. Rotating nights, weekends, holidays and call. Scrub & circulating preferred. *Up to $20,000 sign-on bonus available for external candidates with 2-year commitment. Must have at least 2 years of OR experience. Job Summary/Purpose : Under general...

Part time, Part Time
 
MUSC Health Florence, SC, USA
Job Description Summary Awesome opportunity for an experienced RN looking to work extra shifts! PRN staff at MUSC are eligible to participate in the State Retirement plan. Apply today or contact Recruiter Shannon Shaw at 843-674-2694 or shawsh@musc.edu for more details. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ PRN Cost Center CC003595 FLO - MedSurg 4th Floor (FMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 8 Work Shift Job Description Provides nursing care to patients using the nursing process (assessment, planning, implementation, and evaluation). Directs and leads other assigned team members and collaborates with multidisciplinary team members to provide age/developmentally appropriate care in accordance with nursing standards of care and practice. Provide patient/family centered care using the nursing process and focusing on the physical, emotional, spiritual,...

Full time, Full Time
 
MUSC Health Charleston, SC, USA
Job Description Summary Come join our rapidly growing Atrial Fibrillation Program as an RN Coordinator. The RN Coordinator is responsible for managing and optimizing all aspects of care for patients with atrial fibrillation. This role streamlines communication across the care team, supports evidence-based treatment pathways, facilitates timely follow-up, and ensures each patient receives coordinated, high-quality care throughout their episode of treatment. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC000394 CHS - Device Monitoring Program (ART) Pay Rate Type Salary Pay Grade Health-29 Scheduled Weekly Hours 40 Work Shift Job Description Hours Per Week : 40 Scheduled Work Hours/Shift: Monday-Friday. Hybrid position with 1-2 day in office. Required to travel to outreach clinic (Myrtle Beach) once a month. No major holidays, weekends, or call. Job Summary/Purpose : The...

Full time, Full Time
 
MUSC Health Charleston, SC, USA
Job Description Summary The Registered Nurse II on the NSICU Unit reports to the Nurse Manager. Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process; delivers safe and effective care and interacts with other members of the health care team to achieve desired outcomes. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC000542 CHS - NSICU (Neurosciences ICU) (Main) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Rotating (United States of America) Job Description Hours Per Week : 36 Scheduled Work Hours/Shift: 3 - 12 Hour Rotating Shifts per week, including some weekends Job Summary/Purpose : The Neuroscience Intensive Care was designed and organized to meet the special...

Full time, Full Time
 
MUSC Health Chester, SC, USA
Job Description Summary MUSC Community Physicians (MCP) is an entity within the Medical University of South Carolina that provides healthcare to patients within the rural health network throughout the state of South Carolina. Under the direction of a registered nurse is responsible for all identified nursing care behaviors within his/her span of control during his/her tour of duty and is accountable to the Charge Nurse and/or designated individual. The LPN participates in the care of a defined patient population. The LPN assists with data collection, formulation of plans for patient care, and participates with evaluation of outcomes of nursing actions. Entity MUSC Community Physicians (MCP) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001779 MCP - Chester Med Group Surg Serv Pay Rate Type Hourly Pay Grade Health-24 Scheduled Weekly Hours 40 Work Shift Job Description • Provides patient/family centered care, acting as...

Full time, Full Time
 
MUSC Health Lancaster, SC, USA
Job Description Summary Are you a night owl with a passion for patient care? Join our dedicated Telemetry Unit and become a vital part of our Nightshift Warrior Team. While the world is sleeping, you'll be the heartbeat of our hospital—monitoring, responding, and caring for patients when they need it most. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001507 LAN - MedSurg 5th Floor (LMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Nights (United States of America) Job Description Hours: 36 per a week; 3-12 hour shifts per a week MUSC Lancaster Medical Center Telemetry RNs provide exceptional care to patients who require continuous cardiac monitoring, including those with heart failure, post-cardiac procedures, or other critical conditions. The RN will work collaboratively with physicians, techs, and fellow nurses to ensure optimal...

Full time, Full Time
 
MUSC Health Florence, SC, USA
Job Description Summary Advanced Practice Provider (NP/PA) – Cardiology – MUSC Health Florence Medical Center - Job Summary/ Purpose: The successful applicant will be an Advanced Practice Provider interested in working full-time in the outpatient care of cardiology patients. The APP will provide quality care for patients, coordinate care, and evaluate new and established patients in the clinic. Our Cardiology physicians provide compassionate care for you and your loved ones. Their knowledge of cardiac medicine combined with their concern for the patient's well being makes MUSC Health - Cardiology an excellent choice for your cardiac healthcare needs. Cardiac care at MUSC Health - Cardiology focuses on the functions and disorders of the heart and circulatory system. Our heart care specialists provide routine and preventive cardiac services, as well as help manage chronic conditions. Entity MUSC Community Physicians (MCP) Worker Type Employee Worker Sub-Type​ Regular...

Full time, Full Time
 
MUSC Health Columbia, SC, USA
Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process; delivers safe and effective care and interacts with other members of the health care team to achieve desired results. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC003715 COL - General Surgery (DMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 40 Work Shift Job Description *** $18,000 Sign-On Bonus *** Entity/Organization: MUHA (Medical University Hospital Authority/Medical Center) Hours Per Week : 40 - 7a-7:30p Scheduled Work Hours/Shift: Monday-Friday. Some call required. Job Summary/Purpose : Under general supervision, the Registered Nurse II provides individualized,...

Full time, Full Time
 
MUSC Health Columbia, SC, USA
Job Description Summary Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to families and patients at the competent level utilizing the principles and practices of the nursing process; delivers safe and effective care and interacts with other members of the health care team to achieve desired results. Entity Medical University Hospital Authority (MUHA) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC003715 COL - General Surgery (DMC) Pay Rate Type Hourly Pay Grade Health-28 Scheduled Weekly Hours 36 Work Shift Day (United States of America) Job Description Entity/Organization: MUHA (Medical University Hospital Authority/Medical Center) Hours Per Week : 40 Scheduled Work Hours/Shift: Monday-Friday. Some call required. Job Summary/Purpose : Under general supervision, the Registered Nurse II provides individualized, goal-directed patient care to...